MicroRNAs: new players in IBD

Kalla, R., Ventham, N.T., Kennedy, N.A., Quintana, J.F. , Nimmo, E.R., Buck, A.H. and Satsangi, J. (2015) MicroRNAs: new players in IBD. Gut, 64(3), pp. 504-513. (doi: 10.1136/gutjnl-2014-307891) (PMID:25475103) (PMCID:PMC4345829)

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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Quintana, Dr Juan
Authors: Kalla, R., Ventham, N.T., Kennedy, N.A., Quintana, J.F., Nimmo, E.R., Buck, A.H., and Satsangi, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Gut
Publisher:BMJ Publishing Group
ISSN:0017-5749
ISSN (Online):1468-3288
Published Online:04 December 2014
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Gut 64(3): 504-513
Publisher Policy:Reproduced under a Creative Commons License

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