Oxidative stress and vascular damage in hypertension

Berry, C., Brosnan, M., Fennell, J., Hamilton, C. and Dominiczak, A. (2001) Oxidative stress and vascular damage in hypertension. Current Opinion in Nephrology and Hypertension, 10(2), pp. 247-255.

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Abstract

Oxidative stress, a state of excessive reactive oxidative species activity, is associated with vascular disease states such as hypertension. In this review, we discuss the recent advances in the field of reactive oxidative species-mediated vascular damage in hypertension. These include the identification of redox-sensitive tyrosine kinases, the characterization of enzymatic sources of superoxide production in human blood vessels, and their relationship with vascular damage in atherosclerosis and hypertension. Finally, recent developments in the search for strategies to attenuate vascular oxidative stress are reviewed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Berry, Professor Colin and Hamilton, Dr Carlene and Dominiczak, Professor Anna
Authors: Berry, C., Brosnan, M., Fennell, J., Hamilton, C., and Dominiczak, A.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Current Opinion in Nephrology and Hypertension

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