Improvement of renal diffusion-weighted magnetic resonance imaging with readout-segmented echo-planar imaging at 3T

Friedli, I., Crowe, L. A., Viallon, M., Porter, D. A., Martin, P.-Y., de Seigneux, S. and Vallée, J.-P. (2015) Improvement of renal diffusion-weighted magnetic resonance imaging with readout-segmented echo-planar imaging at 3T. Magnetic Resonance Imaging, 33(6), pp. 701-708. (doi: 10.1016/j.mri.2015.02.023) (PMID:25732925)

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Abstract

Purpose: To assess the feasibility of a respiratory-gated implementation of readout-segmented SE-EPI (RESOLVE) for renal diffusion-weighted imaging (DWI) by comparison with single-shot SE-EPI (ss-EPI) in a phantom, healthy volunteers and chronic kidney disease (CKD) patients. Materials and Methods: A fluid-filled phantom, 20 healthy volunteers and 10 CKD patients were scanned with the same parameters and coils on a 3 T MR system with 3 DW sequences (b-values = 0, 300, 500, 900 s/mm2): a standard ss-EPI (Reference EPI), a ss-EPI with higher resolution, bandwidth and acceleration factor (HR-EPI) and RESOLVE with the same spatial resolution as HR-EPI but a segmentation of the readout into 5 shots. Geometric distortions, image blurring using a ‘Canny’ edge detection based measure, cortico-medullary differentiation measured on b0 images and ADC quantification were compared between the 3 sequences using one-way analysis of variance (ANOVA) with post-hoc Bonferroni (p < 0.05 was taken as statistically significant). Results: RESOLVE reduced significantly geometric distortions and blurring and improved, in the volunteers and patients, the sharpness score by 56% on average in comparison to ss-EPI (p = 0.02). In healthy volunteers, the cortico-medullary differentiation with RESOLVE was also possible on a wider range of b-values (p < 0.02) with ADC values (in 10− 6 mm2/s) of 1994 ± 246 in the cortex and 1762 ± 238 in the medulla (p < 0.001). In CKD patients, ADC values (in 10− 6 mm2/s) from the RESOLVE sequence were not different between the cortex (1755 ± 145) and the medulla (1799 ± 163, p = 0.49). Conclusion: Despite a longer scan time, RESOLVE enhanced significantly the quality of renal diffusion-weighted images by improving the difference in SI and ADC between the renal cortex and medulla in healthy volunteers. In CKD patients, RESOLVE showed a disappearance of this cortico-medullary ADC difference. These improvements justify further clinical studies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Porter, Professor David
Authors: Friedli, I., Crowe, L. A., Viallon, M., Porter, D. A., Martin, P.-Y., de Seigneux, S., and Vallée, J.-P.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Magnetic Resonance Imaging
Publisher:Elsevier
ISSN:0730-725X
ISSN (Online):1873-5894
Published Online:27 February 2015

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