Evaluation of an inflammation-based prognostic score in patients with inoperable pancreatic cancer

Glen, P., Jamieson, N.B., McMillan, D.C. , Carter, R., Imrie, C.W. and Mckay, C.J. (2006) Evaluation of an inflammation-based prognostic score in patients with inoperable pancreatic cancer. Pancreatology, 6(5), pp. 450-453. (doi:10.1159/000094562)

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Abstract

Background/Aims: Patients with pancreatic cancer have one of the poorest survival rates and selection of patients for active treatment remains problematical. The present study assesses the value of an inflammation-based score (Glasgow Prognostic Score, GPS) in patients with inoperable pancreatic cancer. Methods: The GPS was constructed as follows: patients with both an elevated C-reactive protein (>10 mg/l) and hypoalbuminaemia (<35 g/l) were allocated a score of 2. Patients in whom only 1 or none of these biochemical abnormalities was present were allocated a score of 1 or 0, respectively. Results: One hundred and eighty-seven patients were studied and 49 (26%) underwent an operative palliative bypass procedure. At the end of follow-up, 181 (97%) patients died, 17% of patients were alive at 12 months. On univariate analysis, age (p < 0.01), TNM stage (p < 0.001) and the GPS (p < 0.001) were significant predictors of survival. On multivariate survival analysis, stratified for bypass procedure, age (hazard ratio 1.53, 95%CI 1.12–2.10, p = 0.008), TNM stage (hazard ratio 1.70, 95%CI 1.33–2.18, p < 0.001) and the GPS (hazard ratio 1.72, 95%CI 1.40–2.11, p < 0.001) remained independent significant predictors of survival. Conclusion: At diagnosis, the presence of a systemic inflammatory response (as measured by the GPS) appears to be a useful indicator of poor outcome, independent of TNM stage, in patients with inoperable pancreatic cancer.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jamieson, Dr Nigel and McMillan, Professor Donald and Carter, Dr Roger
Authors: Glen, P., Jamieson, N.B., McMillan, D.C., Carter, R., Imrie, C.W., and Mckay, C.J.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Pancreatology
ISSN:1424-3903

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