Reshaping the tumor stroma for treatment of pancreatic cancer

Vennin, C., Murphy, K. J., Morton, J. P. , Cox, T. R., Pajic, M. and Timpson, P. (2018) Reshaping the tumor stroma for treatment of pancreatic cancer. Gastroenterology, 154(4), pp. 820-838. (doi: 10.1053/j.gastro.2017.11.280) (PMID:29287624)

Abstract

Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for reshaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. We also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and discuss the implications for the development of stromal compartment−specific therapies.

• Item Type: Articles
• Additional Information: This work was supported by the National Health and Medical Research Council, National Breast Cancer Foundation, Cancer Institute NSW, an Australian Research Council Future Fellowship, a Len Ainsworth Pancreatic Cancer Fellowship, a Philip Hemstritch Fellowship in Pancreatic Cancer, Avner Pancreatic Cancer Foundation, a Sydney Catalyst scholarship, Cancer Council NSW, Tour de Cure, and a Cancer Research UK core grant.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Morton, Professor Jen and Timpson, Dr Paul
• Authors: Vennin, C., Murphy, K. J., Morton, J. P., Cox, T. R., Pajic, M., and Timpson, P.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Gastroenterology
• Publisher: Elsevier
• ISSN: 0016-5085
• ISSN (Online): 1528-0012
• Published Online: 26 December 2017
• Copyright Holders: Copyright © 2018 AGA Institute
• First Published: First published in Gastroenterology 154(4):820-838
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher