Regulatory T cells in the control of immune pathology

Maloy, K. J. and Powrie, F. (2001) Regulatory T cells in the control of immune pathology. Nature Immunology, 2(9), pp. 816-822. (doi: 10.1038/ni0901-816) (PMID:11526392)

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Abstract

It is now well established that regulatory T (T(R)) cells can inhibit harmful immunopathological responses directed against self or foreign antigens. However, many key aspects of T(R) cell biology remain unresolved, especially with regard to their antigen specificities and the cellular and molecular pathways involved in their development and mechanisms of action. We will review here recent findings in these areas, outline a model for how T(R) cells may inhibit the development of immune pathology and discuss potential therapeutic benefits that may arise from the manipulation of T(R) cell function.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maloy, Professor Kevin
Authors: Maloy, K. J., and Powrie, F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Immunology
Publisher:Nature Publishing Group
ISSN:1529-2908
ISSN (Online):1529-2916

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