Maloy, K. J. and Powrie, F. (2001) Regulatory T cells in the control of immune pathology. Nature Immunology, 2(9), pp. 816-822. (doi: 10.1038/ni0901-816) (PMID:11526392)
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Abstract
It is now well established that regulatory T (T(R)) cells can inhibit harmful immunopathological responses directed against self or foreign antigens. However, many key aspects of T(R) cell biology remain unresolved, especially with regard to their antigen specificities and the cellular and molecular pathways involved in their development and mechanisms of action. We will review here recent findings in these areas, outline a model for how T(R) cells may inhibit the development of immune pathology and discuss potential therapeutic benefits that may arise from the manipulation of T(R) cell function.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Maloy, Professor Kevin |
| Authors: | Maloy, K. J., and Powrie, F. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Nature Immunology |
| Publisher: | Nature Publishing Group |
| ISSN: | 1529-2908 |
| ISSN (Online): | 1529-2916 |
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