Critical role for DNA vaccination frequency in induction of antigen-specific cytotoxic responses

Heinzerling, L., Basch, V., Maloy, K. , Johansen, P., Senti, G., Wüthrich, B., Storni, T. and Kündig, T. M. (2006) Critical role for DNA vaccination frequency in induction of antigen-specific cytotoxic responses. Vaccine, 24(9), pp. 1389-1394. (doi: 10.1016/j.vaccine.2005.09.018) (PMID:16225968)

Full text not currently available from Enlighten.

Abstract

Since antigen-persistence plays a role for induction of immunity, we investigated the in vivo pharmacokinetic of a naked DNA vaccine at the site of its action, i.e., in the lymph node. After direct intralymphatic injection, naked DNA vaccine degraded within a few hours. In correlation with the short persistence of the DNA vaccine we found that the frequency of vaccination critically influenced the strength of the immune response. In mice vaccinated every 3 days, cytotoxic T-cell responses were enhanced compared to immunization in 6 or 9 days intervals. The results suggest that the so far disappointing efficiency of naked DNA vaccines in humans may be overcome by more frequent vaccination.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maloy, Professor Kevin
Authors: Heinzerling, L., Basch, V., Maloy, K., Johansen, P., Senti, G., Wüthrich, B., Storni, T., and Kündig, T. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Vaccine
Publisher:Elsevier
ISSN:0264-410X
ISSN (Online):1873-2518
Published Online:19 September 2005

University Staff: Request a correction | Enlighten Editors: Update this record