Control of intestinal homeostasis by regulatory T cells and dendritic cells

Coombes, J. L. and Maloy, K. J. (2007) Control of intestinal homeostasis by regulatory T cells and dendritic cells. Seminars in Immunology, 19(2), pp. 116-126. (doi: 10.1016/j.smim.2007.01.001) (PMID:17320411)

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Abstract

Many different pathways contribute to the maintenance of tolerance to harmless antigens in the intestine. When these important pathways are compromised, chronic intestinal inflammation can develop. In particular, naturally occurring CD4+CD25+ regulatory T cells have been shown to play an important role in the prevention and cure of colitis in animal models of intestinal inflammation. These regulatory T cell responses may be influenced by the local environment in the intestine. For example, functionally specialised populations of dendritic cells exist in the intestine which may favour regulatory type responses. Understanding how these pathways intersect may lead to the development of more specific therapies for the treatment of inflammatory bowel disease.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maloy, Professor Kevin
Authors: Coombes, J. L., and Maloy, K. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Seminars in Immunology
Publisher:Elsevier
ISSN:1044-5323
ISSN (Online):1096-3618
Published Online:21 February 2007

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