Modulation of immune development and function by intestinal microbiota

Kabat, A. M., Srinivasan, N. and Maloy, K. J. (2014) Modulation of immune development and function by intestinal microbiota. Trends in Immunology, 35(11), pp. 507-517. (doi: 10.1016/j.it.2014.07.010) (PMID:25172617) (PMCID:PMC6485503)

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Abstract

The immune system must constantly monitor the gastrointestinal tract for the presence of pathogens while tolerating trillions of commensal microbiota. It is clear that intestinal microbiota actively modulate the immune system to maintain a mutually beneficial relation, but the mechanisms that maintain homeostasis are not fully understood. Recent advances have begun to shed light on the cellular and molecular factors involved, revealing that a range of microbiota derivatives can influence host immune functions by targeting various cell types, including intestinal epithelial cells, mononuclear phagocytes, innate lymphoid cells, and B and T lymphocytes. Here, we review these findings, highlighting open questions and important challenges to overcome in translating this knowledge into new therapies for intestinal and systemic immune disorders.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maloy, Professor Kevin
Authors: Kabat, A. M., Srinivasan, N., and Maloy, K. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Immunology
Publisher:Elsevier
ISSN:1471-4906
ISSN (Online):1471-4981
Published Online:27 August 2014

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