Kabat, A. M., Srinivasan, N. and Maloy, K. J. (2014) Modulation of immune development and function by intestinal microbiota. Trends in Immunology, 35(11), pp. 507-517. (doi: 10.1016/j.it.2014.07.010) (PMID:25172617) (PMCID:PMC6485503)
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Abstract
The immune system must constantly monitor the gastrointestinal tract for the presence of pathogens while tolerating trillions of commensal microbiota. It is clear that intestinal microbiota actively modulate the immune system to maintain a mutually beneficial relation, but the mechanisms that maintain homeostasis are not fully understood. Recent advances have begun to shed light on the cellular and molecular factors involved, revealing that a range of microbiota derivatives can influence host immune functions by targeting various cell types, including intestinal epithelial cells, mononuclear phagocytes, innate lymphoid cells, and B and T lymphocytes. Here, we review these findings, highlighting open questions and important challenges to overcome in translating this knowledge into new therapies for intestinal and systemic immune disorders.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Maloy, Professor Kevin |
| Authors: | Kabat, A. M., Srinivasan, N., and Maloy, K. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Trends in Immunology |
| Publisher: | Elsevier |
| ISSN: | 1471-4906 |
| ISSN (Online): | 1471-4981 |
| Published Online: | 27 August 2014 |
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