Metabolic adaptations of CD4+ T Cells in inflammatory disease

Dumitru, C., Kabat, A. M. and Maloy, K. J. (2018) Metabolic adaptations of CD4+ T Cells in inflammatory disease. Frontiers in Immunology, 9, 540. (doi: 10.3389/fimmu.2018.00540) (PMID:29599783) (PMCID:PMC5862799)

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Abstract

A controlled and self-limiting inflammatory reaction generally results in removal of the injurious agent and repair of the damaged tissue. However, in chronic inflammation, immune responses become dysregulated and prolonged, leading to tissue destruction. The role of metabolic reprogramming in orchestrating appropriate immune responses has gained increasing attention in recent years. Proliferation and differentiation of the T cell subsets that are needed to address homeostatic imbalance is accompanied by a series of metabolic adaptations, as T cells traveling from nutrient-rich secondary lymphoid tissues to sites of inflammation experience a dramatic shift in microenvironment conditions. How T cells integrate information about the local environment, such as nutrient availability or oxygen levels, and transfer these signals to functional pathways remains to be fully understood. In this review, we discuss how distinct subsets of CD4+ T cells metabolically adapt to the conditions of inflammation and whether these insights may pave the way to new treatments for human inflammatory diseases.

Item Type:Articles
Additional Information:KM is funded by a Wellcome Trust Investigator Award (102972) and by an MRC project grant (MR/N02379X/1). CD is supported by a Heatley-Merck, Sharp and Dohme studentship. AK is supported by a Humboldt Foundation postdoctoral fellowship.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maloy, Professor Kevin
Authors: Dumitru, C., Kabat, A. M., and Maloy, K. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Frontiers in Immunology
Publisher:Frontiers Media
ISSN:1664-3224
ISSN (Online):1664-3224
Published Online:15 March 2018
Copyright Holders:Copyright © 2018 Dumitru, Kabat and Maloy
First Published:First published in Frontiers in Immunology 9:540
Publisher Policy:Reproduced under a Creative Commons license

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