Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis

Pott, J. and Maloy, K. J. (2018) Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis. Autophagy, 14(8), pp. 1460-1461. (doi: 10.1080/15548627.2018.1450021) (PMID:29799774) (PMCID:PMC6103553)

Abstract

Genome-wide association studies (GWAS) linking polymorphisms in ATG16L1 with susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to investigate the functional roles of macroautophagy/autophagy in different cell types in the gut. Here we present a recent study that addressed 2 key questions: in which cell type is autophagy deficiency most detrimental during chronic colitis and what is the functional role of autophagy in those cells? We report that autophagy in intestinal epithelial cells (IECs) acts to limit intestinal inflammation by protecting them from TNF-induced apoptosis and we discuss the potential implications for IBD treatment.

• Item Type: Articles
• Additional Information: Funding: Medical Research Foundation [grant number MR/N02379X/1]; Wellcome Trust [grant number 102972].
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Maloy, Professor Kevin
• Authors: Pott, J., and Maloy, K. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Autophagy
• Publisher: Taylor and Francis
• ISSN: 1554-8627
• ISSN (Online): 1554-8635
• Published Online: 25 May 2018
• Copyright Holders: Copyright © 2018 The Authors
• First Published: First published in Autophagy 14(8):1460-1461
• Publisher Policy: Reproduced under a Creative Commons license