Veltel, S., Kravchenko, A., Ismail, S. and Wittinghofer, A. (2008) Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex. FEBS Letters, 582(17), pp. 2501-2507. (doi: 10.1016/j.febslet.2008.05.053) (PMID:18588884)
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Abstract
Arl2 and Arl3, members of the Arf subfamily of smallG proteins, are believed to be involved in ciliary and microtubule-dependent processes. Recently, we could identify RP2, responsi-ble for a variant of X-linked retinitis pigmentosa, as the Arl3-specific GAP. Here, we have characterized Arl2/3 interactions.We show the formation of a ternary complex between Arl3, itscognate GAP RP2 and its retinal effector HRG4. This complexseems to be important for photoreceptor function.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Ismail, Dr Shehab |
| Authors: | Veltel, S., Kravchenko, A., Ismail, S., and Wittinghofer, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | FEBS Letters |
| Publisher: | Elsevier |
| ISSN: | 0014-5793 |
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