Neural oscillations and connectivity characterizing the state of tonic experimental pain in humans

Nickel, M. M., Ta Dinh, S., May, E. S., Tiemann, L., Hohn, V. D., Gross, J. and Ploner, M. (2020) Neural oscillations and connectivity characterizing the state of tonic experimental pain in humans. Human Brain Mapping, 41(1), pp. 17-29. (doi: 10.1002/hbm.24784) (PMID:31498948) (PMCID:PMC7267966)

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Abstract

Pain is a complex phenomenon that is served by neural oscillations and connectivity involving different brain areas and frequencies. Here, we aimed to systematically and comprehensively assess the pattern of neural oscillations and connectivity characterizing the state of tonic experimental pain in humans. To this end, we applied 10-min heat pain stimuli consecutively to the right and left hand of 39 healthy participants and recorded electroencephalography. We systematically analyzed global and local measures of oscillatory brain activity, connectivity, and graph theory-based network measures during tonic pain and compared them to a nonpainful control condition. Local measures showed suppressions of oscillatory activity at alpha frequencies together with stronger connectivity at alpha and beta frequencies in sensorimotor areas during tonic pain. Furthermore, sensorimotor areas contralateral to stimulation showed significantly increased connectivity to a common area in the medial prefrontal cortex at alpha frequencies. Together, these observations indicate that the state of tonic experimental pain is associated with a sensorimotor-prefrontal network connected at alpha frequencies. These findings represent a step further toward understanding the brain mechanisms underlying long-lasting pain states in health and disease.

Item Type:Articles
Additional Information:Funding information Bayerisches Staatsministerium für Bildung und Kultus, Wissenschaft und Kunst; Deutsche Forschungsgemeinschaft, Grant/Award Numbers: PL321/10-1, PL321/10-2, PL321/11-1, PL321/11-2; Wellcome Trust, Grant/Award Number: 098433
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gross, Professor Joachim
Authors: Nickel, M. M., Ta Dinh, S., May, E. S., Tiemann, L., Hohn, V. D., Gross, J., and Ploner, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Human Brain Mapping
Publisher:Wiley
ISSN:1065-9471
ISSN (Online):1097-0193
Published Online:09 September 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Human Brain Mapping 41(1): 17-29
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
167204Natural and modulated neural communication: State-dependent decoding and driving of human Brain Oscillations.Joachim GrossWellcome Trust (WELLCOTR)098433/Z/12/ZNP - Centre for Cognitive Neuroimaging (CCNi)