The metabolome identity: basis for discovery of biomarkers in neurodegeneration

Steinert, J. R. and Bourgognon, J.-M. (2018) The metabolome identity: basis for discovery of biomarkers in neurodegeneration. Neural Regeneration Research, 14(3), pp. 387-390. (doi: 10.4103/1673-5374.245464) (PMID:30539802) (PMCID:PMC6334598)

Abstract

Neurodegenerative disorders are often associated with cellular dysfunction caused by underlying protein-misfolding signalling. Numerous neuropathologies are diagnosed at late stage symptomatic changes which occur in response to these molecular malfunctions and treatment is often too late or restricted only to the slowing of further cell death. Important new strategies to identify early biomarkers with predictive value to intervene with disease progression at stages where cell dysfunction has not progressed irreversibly is of paramount importance. Thus, the identification of these markers presents an essential opportunity to identify and target disease pathways. This review highlights some important metabolic alterations detected in neurodegeneration caused by misfolded prion protein and discusses common toxicity pathways identified across different neurodegenerative diseases. Thus, having established some commonalities between various degenerative conditions, detectable metabolic changes may be of extreme value as an early diagnostic biomarker in disease.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Bourgognon, Dr Julie-Myrtille
• Authors: Steinert, J. R., and Bourgognon, J.-M.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing
• Journal Name: Neural Regeneration Research
• Publisher: Medknow Publications
• ISSN: 1673-5374
• ISSN (Online): 1876-7958
• Copyright Holders: Copyright © 2018 Neural Regeneration Research
• First Published: First published in Neural Regeneration Research 14(3):387-390
• Publisher Policy: Reproduced under a Creative Commons License