Neuroaxonal dystrophy in a litter of papillon pups

Franklin, R.J.M., Jeffery, N.D. and Ramsey, I.K. (1995) Neuroaxonal dystrophy in a litter of papillon pups. Journal of Small Animal Practice, 36(10), pp. 441-444. (doi:10.1111/j.1748-5827.1995.tb02774.x) (PMID:8583759)

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Abstract

A litter of five 14‐week‐old papillon puppies was referred for investigation of pelvic limb ataxia. Clinical examination revealed signs of ataxia, hypermetria and depressed postural reflexes affecting all four limbs. The severity of these signs varied between members of the litter. The condition became progressively worse and by 19 weeks of age all but the least severely affected pup (the single male of the litter) had deteriorated to the point that euthanasia was indicated on humane grounds. Pathological examination revealed widespread changes in both white and grey matter of the neuraxis caudal to the fore‐brain, particularly involving the dorsolateral white matter of the spinal cord, which were characterised by axonal swellings typical of neuroaxonal dystrophy.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ramsey, Professor Ian
Authors: Franklin, R.J.M., Jeffery, N.D., and Ramsey, I.K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Journal of Small Animal Practice
Publisher:Wiley
ISSN:0022-4510
ISSN (Online):1748-5827

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