Hexose transport in asexual stages of Plasmodium falciparum and Kinetoplastidae

Krishna, S., Woodrow, C.J., Burchmore, R.J.S. , Saliba, K.J. and Kirk, K. (2000) Hexose transport in asexual stages of Plasmodium falciparum and Kinetoplastidae. Parasitology Today, 16(12), pp. 516-521. (doi: 10.1016/s0169-4758(00)01762-2) (PMID:11121848)

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Abstract

The hexose sugar, glucose, is a vital energy source for most organisms and an essential nutrient for asexual stages of Plasmodium falciparum. Kinetoplastid organisms (e.g. Trypanosoma and Leishmania spp) also require glucose at certain critical stages of their life cycles. Although phylogenetically unrelated, these organisms share many common challenges during the mammalian stages of a parasitic life cycle, and possess hexose uptake mechanisms that are amenable to study using similar methods. Defining hexose permeation pathways into parasites might expose an Achilles’ heel at which both antidisease and antiparasite measures can be aimed. Understanding the mode of entry of glucose also presents a good general model for substrate acquisition in multicompartment systems. In this review, Sanjeev Krishna and colleagues summarize current understanding of hexose transport processes in P. falciparum and provide a comparison with data obtained from kinetoplastids.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Burchmore, Dr Richard
Authors: Krishna, S., Woodrow, C.J., Burchmore, R.J.S., Saliba, K.J., and Kirk, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Parasitology Today
Publisher:Elsevier
ISSN:0169-4758
ISSN (Online):1873-1473
Published Online:13 December 2000

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