The plasma proteome and acute phase proteins of broiler chickens with gait abnormalities

O'Reilly, E.L., Burchmore, R.J. , Sandilands, V., Sparks, N.H., Walls, C. and Eckersall, P.D. (2012) The plasma proteome and acute phase proteins of broiler chickens with gait abnormalities. In: Rodrigues, P., Eckersall, D. and de Almeida, A. (eds.) Farm Animal Proteomics: Proceedings of the 3rd Managing Committee Meeting and 2nd Meeting of Working Groups 1, 2 & 3 of COST Action FA1002. Series: Topics in safety, reliability, and quality (18). Wageningen Academic Publishers: Wageningen, pp. 177-180. ISBN 9789086861958 (doi:10.3920/978-90-8686-751-6_42)

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Abstract

The acute phase response (APR) is the early and non-specific systemic reaction of the innate immune system to homeostatic disturbances. Pro-inflammatory cytokines and chemokines released from macrophages, monocytes and infected and damaged tissues affect the synthesis and secretion of hepatocytic proteins and drastically alter the plasma protein profile. Plasma proteins that change concentrations as a result of an APR are termed acute phase proteins (APPs). The measurable changes in APP concentrations during infectious, inflammatory, stressful, traumatic or neoplastic events are often proportional to the severity of the event(s). As such APP measurements are used as disease biomarkers and for prognostication.

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Burchmore, Dr Richard and Eckersall, Professor David and Sparks, Dr Nicholas and O'Reilly, Dr Emily
Authors: O'Reilly, E.L., Burchmore, R.J., Sandilands, V., Sparks, N.H., Walls, C., and Eckersall, P.D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Publisher:Wageningen Academic Publishers
ISBN:9789086861958

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