Proteomics at the host: pathogen interface

Burchmore, R. (2013) Proteomics at the host: pathogen interface. In: de Almeida, A., Eckersall, D., Bencurova, E., Dolinska, S., Mlynarcik, P., Vincova, M. and Bhide, M. (eds.) Farm Animal Proteomics 2013: Proceedings of the 4th Management Committee Meeting and 3rd Meeting of Working Groups 1, 2 & 3 of COST Action FA1002 Košice, Slovakia 25-26 April 2013. Wageningen Academic Publishers: Wageningen, p. 37. ISBN 9789086862221 (doi: 10.3920/978-90-8686-776-9_11)

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Abstract

The surface membrane of cells is the interface with the environment. The lipid membrane is impermeable, so the uptake of molecules by the cell must be facilitated by the action of integral membrane proteins. These proteins, which include transporters, channels and receptors, mediate communication between the cell and the environment and are thus key to all cellular processes. In pathogens, surface membrane proteins represent the interface with the host and the primary route by which drugs can access their targets. Understanding the expression, structure and function of pathogen membrane proteins is central to understanding host:pathogen interactions and offers many possibilities for control of infection.

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Burchmore, Dr Richard
Authors: Burchmore, R.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Publisher:Wageningen Academic Publishers
ISBN:9789086862221

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