Standardisation of synovial tissue infiltrate analysis: how far have we come? how much further do we need to go?

Baeten, D., Bresnihan, B., Fitzgerald, O., McInnes, I. , Smith, M., Tak, P., Ulfgren, A. and Veale, D. (2006) Standardisation of synovial tissue infiltrate analysis: how far have we come? how much further do we need to go? Annals of the Rheumatic Diseases, 65, pp. 93-100. (doi:10.1136/ard.2005.036905) (PMID:15975970) (PMCID:PMC1797968)

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Abstract

Changes in cellular infiltrate and expression of cytokines, chemokines, and cell adhesion molecules as a result of therapeutic interventions in rheumatoid arthritis can be demonstrated in the synovial membrane. However, before synovial tissue analysis can be used as an outcome measure in such studies, standardisation of the site and method of synovial tissue acquisition, methods of tissue processing, and appropriate methods of detection and measurement of cell lineage specific markers and relevant biological proteins is needed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain
Authors: Baeten, D., Bresnihan, B., Fitzgerald, O., McInnes, I., Smith, M., Tak, P., Ulfgren, A., and Veale, D.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Annals of the Rheumatic Diseases
Publisher:B M J Group
ISSN:0003-4967
ISSN (Online):1468-2060

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