Genetics of hypertension: Lessons learnt from Mendelian and polygenic syndromes

Dominiczak, A. , Brain, N., Charchar, F., McBride, M. , Hanlon, N. and Lee, W. (2004) Genetics of hypertension: Lessons learnt from Mendelian and polygenic syndromes. Clinical and Experimental Hypertension, 26(7-8), pp. 611-620. (doi:10.1081/CEH-200031939)

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Abstract

This brief review discusses genetic and genomic aspects of hypertension. A special emphasis is given to currently available strategies for gene identifications, including studies of rare Mendelian hypertension, candidate gene evaluation, genome‐wide scans and approaches based on the comparative genome analysis. We also discuss the growing potential for pharmacogenetic approaches and address briefly the issue of genetic testing in complex polygenic traits.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McBride, Dr Martin and Dominiczak, Professor Anna
Authors: Dominiczak, A., Brain, N., Charchar, F., McBride, M., Hanlon, N., and Lee, W.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Clinical and Experimental Hypertension
ISSN:1064-1963

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