Investigating the immunologic effects of CoCr nanoparticles

Ogunwale, B., Schmidt-Ott, A., Meek, R. M. D. and Brewer, J. M. (2009) Investigating the immunologic effects of CoCr nanoparticles. Clinical Orthopaedics and Related Research, 467(11), 3010. (doi: 10.1007/s11999-009-0949-9) (PMID:19565304) (PMCID:PMC2758989)

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Abstract

The increase in metal-on-metal hip arthroplasties has led to concern regarding the effect of raised serum and tissue metal ion levels. Our aim was to determine changes in the integrity and function of cells of the immune system after exposure to CoCr nanoparticles in specific cell culture experiments. Nanometer-sized particles of CoCr were made from a manufacturer’s forged CoCr used for metal-on-metal articulations. Primary, murine dendritic cells and T and B lymphocytes then were exposed to these CoCr particles under cell culture conditions and then assayed for viability and proliferation/activation. CoCr nanoparticles did not directly activate dendritic cells or regulate B cells. Although nanoparticles were not directly toxic to resting T cells, Signals 1- and 2-dependent T cell proliferation were reduced. This may explain the observed reduction in CD8+ T cells observed in patients with metal-on-metal implants.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Brewer, Professor James and Meek, Professor Robert
Authors: Ogunwale, B., Schmidt-Ott, A., Meek, R. M. D., and Brewer, J. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Clinical Orthopaedics and Related Research
Publisher:Springer
ISSN:0009-921X
ISSN (Online):1528-1132
Published Online:30 June 2009

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