Hill, S. C. et al. (2015) Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae. Journal of General Virology, 96(6), pp. 1411-1422. (doi: 10.1099/vir.0.000071) (PMID:25626684) (PMCID:PMC4635489)
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Abstract
Polyomaviruses infect a diverse range of mammalian and avian hosts, and are associated with a variety of symptoms. However, it is unknown whether the viruses are found in all mammalian families and the evolutionary history of the polyomaviruses is still unclear. Here, we report the discovery of a novel polyomavirus in the European badger (Meles meles), which to our knowledge represents the first polyomavirus to be characterized in the family Mustelidae, and within a European carnivoran. Although the virus was discovered serendipitously in the supernatant of a cell culture inoculated with badger material, we subsequently confirmed its presence in wild badgers. The European badger polyomavirus was tentatively named Meles meles polyomavirus 1 (MmelPyV1). The genome is 5187 bp long and encodes proteins typical of polyomaviruses. Phylogenetic analyses including all known polyomavirus genomes consistently group MmelPyV1 with California sea lion polyomavirus 1 across all regions of the genome. Further evolutionary analyses revealed phylogenetic discordance amongst polyomavirus genome regions, possibly arising from evolutionary rate heterogeneity, and a complex association between polyomavirus phylogeny and host taxonomic groups.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Cotten, Professor Matthew |
Authors: | Hill, S. C., Murphy, A. A., Cotten, M., Palser, A. L., Benson, P., Lesellier, S., Gormley, E., Richomme, C., Grierson, S., Ni Bhuachalla, D., Chambers, M., Kellam, P., Boschiroli, M.-L., Ehlers, B., Jarvis, M. A., and Pybus, O. G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Journal of General Virology |
Publisher: | Microbiology Society |
ISSN: | 0022-1317 |
ISSN (Online): | 1465-2099 |
Published Online: | 01 June 2015 |
Copyright Holders: | Copyright © 2015 The Authors |
First Published: | First published in Journal of General Virology 96(6): 1411-1422 |
Publisher Policy: | Reproduced under a Creative Commons License |
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