Chitosan-Graphene Oxide Based Ultra-Thin Conformable Sensing Patch for Cell-Health Monitoring

Kafi, M. A., Paul, A., Vilouras, A. and Dahiya, R. (2018) Chitosan-Graphene Oxide Based Ultra-Thin Conformable Sensing Patch for Cell-Health Monitoring. In: 2018 IEEE Sensors, New Delhi, India, 28-31 Oct 2018, ISBN 9781538647073 (doi:10.1109/ICSENS.2018.8589782)

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Abstract

The work presents a Chitosan-Graphene Oxide (Chi-GO) based ultra-thin sensors patch having arrays of gold (Au) based micro-gap (\pmb60μ m) electrode. The cross-linked GO is shown to improve the stability of chitosan substrate in aqueous medium. With human dermal fibroblast (HDF) cell immobilized Chi-GO surface, the sensor patch has been evaluated for label free monitoring. The cyclic voltammetry (CV) of cell immobilized chi-GO surface showed quasi-reversible nature with characteristic cathodic peak at + 300mV and anodic peak - 300mV. Both peaks are stable and repeatable up to 50-scan cycle without any potential shift. The device shows steady state peak enhancement (1.923-11.195nA) with the growth period (O-96h). The redox peak enhancement correlates with the proliferation rates of cell over time, indicating that it could be employed to investigate cyto-physiologic state against any endo and exogenous stimulation. The new compatibility of cross-linked chitosan with microfabrication steps and the ability of presented sensor patch to monitor cell-health will benefit a range of in vivo applications.

Item Type:Conference Proceedings
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kafi, Md Abdul and Vilouras, Anastasios and Dahiya, Professor Ravinder and Paul, Dr Ambarish
Authors: Kafi, M. A., Paul, A., Vilouras, A., and Dahiya, R.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
ISSN:2168-9229
ISBN:9781538647073
Published Online:27 December 2018
Copyright Holders:Copyright © 2018 IEEE
First Published:First published in 2018 IEEE Sensors
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
172808BENDRavinder DahiyaEuropean Commission (EC)704807ENG - Electronics & Nanoscale Engineering
170185Engineering Fellowships for Growth: Printed Tactile SKINRavinder DahiyaEngineering and Physical Sciences Research Council (EPSRC)EP/M002527/1ENG - Electronics & Nanoscale Engineering