Intravital microscopy: imaging host‐parasite interactions in lymphoid organs

De Niz, M., Meehan, G. R. and Tavares, J. (2019) Intravital microscopy: imaging host‐parasite interactions in lymphoid organs. Cellular Microbiology, 21(12), e13117. (doi: 10.1111/cmi.13117) (PMID:31512335)

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Abstract

Intravital microscopy allows imaging of biological phenomena within living animals, including host‐parasite interactions. This has advanced our understanding of both, the function of lymphoid organs during parasitic infections, and the effect of parasites on such organs to allow their survival. In parasitic research, recent developments in this technique have been crucial for the direct study of host –parasite interactions within organs at depths, speeds, and resolution previously difficult to achieve. Lymphoid organs have gained more attention as we start to understand their function during parasitic infections and the effect of parasites on them. In this review, we summarize technical and biological findings achieved by intravital microscopy with respect to the interaction of various parasites with host lymphoid organs, namely the bone marrow, thymus, lymph nodes, spleen, and the mucosa‐associated lymphoid tissue, and present a view into possible future applications.

Item Type:Articles
Additional Information:MDN was funded by Long Term EMBO Postdoctoral fellowship ALTF 1048‐2016. JT is funded by the Portuguese Foundation for Science and Technology (FCT) Grants CEECIND/02362/2017 and PTDC/SAU‐PAR/31340/2017.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Meehan, Dr Gavin and De Niz, Dr Mariana
Authors: De Niz, M., Meehan, G. R., and Tavares, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Cellular Microbiology
Publisher:Wiley
ISSN:1462-5814
ISSN (Online):1462-5822
Published Online:11 September 2019
Copyright Holders:Copyright © 2019 John Wiley and Sons Ltd
First Published:First published in Cellular Microbiology 21(12):e13117
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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