De Niz, M., Meehan, G. R. and Tavares, J. (2019) Intravital microscopy: imaging host‐parasite interactions in lymphoid organs. Cellular Microbiology, 21(12), e13117. (doi: 10.1111/cmi.13117) (PMID:31512335)
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Abstract
Intravital microscopy allows imaging of biological phenomena within living animals, including host‐parasite interactions. This has advanced our understanding of both, the function of lymphoid organs during parasitic infections, and the effect of parasites on such organs to allow their survival. In parasitic research, recent developments in this technique have been crucial for the direct study of host –parasite interactions within organs at depths, speeds, and resolution previously difficult to achieve. Lymphoid organs have gained more attention as we start to understand their function during parasitic infections and the effect of parasites on them. In this review, we summarize technical and biological findings achieved by intravital microscopy with respect to the interaction of various parasites with host lymphoid organs, namely the bone marrow, thymus, lymph nodes, spleen, and the mucosa‐associated lymphoid tissue, and present a view into possible future applications.
| Item Type: | Articles |
|---|---|
| Additional Information: | MDN was funded by Long Term EMBO Postdoctoral fellowship ALTF 1048‐2016. JT is funded by the Portuguese Foundation for Science and Technology (FCT) Grants CEECIND/02362/2017 and PTDC/SAU‐PAR/31340/2017. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Meehan, Dr Gavin and De Niz, Dr Mariana |
| Authors: | De Niz, M., Meehan, G. R., and Tavares, J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Cellular Microbiology |
| Publisher: | Wiley |
| ISSN: | 1462-5814 |
| ISSN (Online): | 1462-5822 |
| Published Online: | 11 September 2019 |
| Copyright Holders: | Copyright © 2019 John Wiley and Sons Ltd |
| First Published: | First published in Cellular Microbiology 21(12):e13117 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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