Co-induction of anaesthesia with alfaxalone and midazolam in dogs: a randomized, blinded clinical trial

Miller, C., Hughes, E. and Gurney, M. (2019) Co-induction of anaesthesia with alfaxalone and midazolam in dogs: a randomized, blinded clinical trial. Veterinary Anaesthesia and Analgesia, 46(5), pp. 613-619. (doi: 10.1016/j.vaa.2019.03.009) (PMID:31285156)

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Abstract

Objective: To qualitatively assess the co-induction of anaesthesia with midazolam and alfaxalone and to determine cardiovascular or respiratory alterations compared with alfaxalone alone. Study design: A randomized, blinded, clinical trial. Animals: A total of 29 American Society of Anesthesiologists grade I or II, client-owned dogs undergoing elective orthopaedic or soft tissue surgery. Methods: All dogs received 0.02 mg kg–1 acepromazine and 0.3 mg kg–1 methadone intramuscularly 30 minutes prior to anaesthesia. Measurements of heart rate (HR), respiratory frequency and blood pressure (BP) were assessed pre-induction and at 0, 2 and 5 minutes post-induction. Anaesthesia was induced with 0.5 mg kg–1 alfaxalone followed by either 0.4 mg kg–1 midazolam intravenously (group M) or an equal volume of saline (group S). Conditions were assessed for intubation and further boluses of 0.25 mg kg–1 alfaxalone were given as required. Response to co-induction, ease of intubation and quality of induction were scored, and total dose of alfaxalone required for intubation was recorded. Repeated measures one-way analysis of variance with post hoc Tukey’s test was used to assess within group changes over time and Student t tests were used to compare between groups. Incidence of apnoea was assessed using a Fisher’s exact test. Data are shown as mean ± standard deviation. Results: Group M included 14 dogs and group S 15 dogs. There was a significant difference in the total dose of alfaxalone required for intubation, 0.65 ± 0.20 mg kg–1 group M and 0.94 ± 0.26 mg kg–1 group S (p = 0.002). Apnoea occurred significantly more frequently in group M (p = 0.007). There were no clinically significant differences in HR or BP at the measured time points between groups. Conclusions and clinical relevance: Co-induction with midazolam had significant alfaxalone-sparing effects with no clinically detectable cardiovascular changes. Apnoea is common after co-induction.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hughes, Ellen and Miller, Chris
Authors: Miller, C., Hughes, E., and Gurney, M.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Veterinary Anaesthesia and Analgesia
Publisher:Elsevier
ISSN:1467-2987
ISSN (Online):1467-2995
Published Online:08 June 2019

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