Effects of smoking on non-surgical periodontal therapy in patients with periodontitis stage III or IV, and grade C

Kanmaz, B., Lappin, D. F., Nile, C. J. and Buduneli, N. (2020) Effects of smoking on non-surgical periodontal therapy in patients with periodontitis stage III or IV, and grade C. Journal of Periodontology, 91(4), pp. 442-453. (doi: 10.1002/JPER.19-0141) (PMID:31448829)

195387.pdf - Accepted Version



Background: To evaluate possible effects of smoking on clinical, biochemical, and microbiological outcomes of non‐surgical periodontal treatment in patients with periodontitis stage III or IV and grade C. Methods: Conventional quadrant‐wise non‐surgical periodontal treatment was performed and whole‐mouth periodontal measurements were recorded at baseline, 1, 3, and 6 months after completion of treatment. Saliva, gingival crevicular fluid, subgingival plaque, and blood samples were obtained at the same time points. Inflammatory cytokine levels, presence, and quantities of 11 different bacterial species were determined. Smoking status was validated by cotinine assay. Results: Fourteen smoker and 13 non‐smoker patients completed the study protocol and revealed similar clinical findings except for the higher plaque scores in the non‐smokers at 6 months (P <0.01). Significant differences were found between the study groups in biofluid cytokine levels at 1 and 3 months (P <0.01). Gram‐negative bacteria were more abundant in the smokers at baseline and so were Gram‐positive bacteria in the non‐smokers (P <0.01). Gram‐negative bacteria repopulated in the smokers faster than in the non‐smokers (P <0.01). Conclusions: The present findings suggest that smoker patients with periodontitis stage III and IV, grade C respond well to the non‐surgical periodontal treatment during the 6‐month follow‐up. However, smokers exhibit faster repopulation of Gram‐negative bacteria.

Item Type:Articles
Additional Information:This study was supported by a grant from the Ege University Research Foundation (Project No: 2014 DIS 013) and funds from the University of Glasgow.
Keywords:Bacteria, cytokines, gingival crevicular fluid, periodontitis, smoking.
Glasgow Author(s) Enlighten ID:Lappin, Dr David and Nile, Dr Christopher
Authors: Kanmaz, B., Lappin, D. F., Nile, C. J., and Buduneli, N.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Journal of Periodontology
ISSN (Online):1943-3670
Published Online:26 August 2019
Copyright Holders:Copyright © 2019 American Academy of Periodontology
First Published:First published in Journal of Periodontology 91(4): 442-453
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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