Gene-modified dendritic cells by receptor-mediated transfection

Diebold, S. S., Cotten, M. , Wagner, E. and Zenke, M. (1998) Gene-modified dendritic cells by receptor-mediated transfection. Advances in Experimental Medicine and Biology, 451, pp. 449-455. (doi: 10.1007/978-1-4615-5357-1_69) (PMID:10026910)

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Abstract

Dendritic cells (DC) are professional antigen presenting cells and represent a particular attractive cell type for use in immunotherapy of cancer1–3. In experimental model systems peptide/protein-pulsed or gene-modified DC are currently being used and have been shown to induce strong anti-tumor immune responses4–11. The application of gene-modified DC is especially appealing since over the past several years an even increasing number of tumor cell-specific and/or -associated antigens has been identified and molecular cloned. Furthermore, gene-modified DC offer the opportunity to express, in addition to tumor-specific antigens, e.g., chemokines and cytokines that attract T cells and modulate T cell responses. However, so far efficient gene transfer into primary immunocompetent DC has remained difficult.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cotten, Professor Matthew
Authors: Diebold, S. S., Cotten, M., Wagner, E., and Zenke, M.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Advances in Experimental Medicine and Biology
Publisher:Springer
ISSN:0065-2598

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