Jobarteh, M. et al. (2010) Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians. Virology Journal, 7, 230. (doi: 10.1186/1743-422x-7-230) (PMID:20843322) (PMCID:PMC2949835)
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Abstract
Background: The prevalence of HIV/hepatitis co-infection in sub-Saharan Africa is not well documented, while both HIV and HBV are endemic in this area. Objective: The aim of this study is to determine the seroprevalence of HBV and HCV virus in HIV-infected subjects in the Gambia. Methods: Plasma samples from HIV infected patients (190 individuals with clinically defined AIDS and 382 individuals without AIDS) were tested retrospectively for the presence of HBV sero-markers and for serum HBV DNA, screened for HCV infection by testing for anti-HCV antibody and HCV RNA. Results: HBsAg prevalence in HIV-positive individuals is 12.2%. HIV/HBV co-infected individuals with CD4 count of <200 cells uL-1 have a higher HBV DNA viral load than patients with higher CD4 count (log 4.0 vs. log 2.0 DNA copies/ml, p < 0.05). Males (OR = 1.8, 95% CI: 1.0, 3.2) were more likely to be HBsAg positive than female. HCV seroprevalence was 0.9% in HIV-positive individuals. Conclusion: The prevalence of HBsAg carriage in HIV- infected Gambians is similar to that obtained in the general population. However co-infected individuals with reduced CD4 levels, indicative of AIDS had higher prevalence of HBeAg retention and elevated HBV DNA levels compared to non-AIDS patients with higher CD4 count.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cotten, Professor Matthew |
| Authors: | Jobarteh, M., Malfroy, M., Peterson, I., Jeng, A., Sarge-Njie, R., Alabi, A., Peterson, K., Cotten, M., Hall, A., Rowland-Jones, S., Whittle, H., Tedder, R., Jaye, A., and Mendy, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Virology Journal |
| Publisher: | BioMed Central |
| ISSN: | 1743-422X |
| ISSN (Online): | 1743-422X |
| Copyright Holders: | Copyright © 2010 Jobarteh et al. |
| First Published: | First published in Virology Journal 7: 230 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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