Diagnosis of adenomatous primary aldosteronism in a patient with severe hypertension

Freel, E. M. and Connell, J. M. C. (2005) Diagnosis of adenomatous primary aldosteronism in a patient with severe hypertension. Nature Clinical Practice Endocrinology and Metabolism, 1(2), pp. 111-115. (doi:10.1038/ncpendmet0047)

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Publisher's URL: http://dx.doi.org/10.1038/ncpendmet0047

Abstract

Background A 27-year-old woman presented to her primary-care physician with severe hypertension after complaining of fatigue over the preceding months. She was otherwise asymptomatic. She was referred to a hypertension clinic and was found to be hypokalemic. She was immediately commenced on amlodipine, with atenolol added 2 weeks later. After 4 weeks of this drug therapy, her hypertension persisted and investigations to exclude secondary causes of hypertension were performed.

Investigations Aldosterone and renin levels were measured under controlled conditions and the results expressed as an aldosterone-to-renin ratio. CT of the adrenal glands was also performed.

Diagnosis Adenomatous primary aldosteronism (Conn's syndrome).

Management The patient was initially treated with spironolactone before undergoing a laparoscopic left adrenalectomy.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Connell, Professor John and Freel, Dr Marie
Authors: Freel, E. M., and Connell, J. M. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Nature Clinical Practice Endocrinology and Metabolism
Publisher:Nature Publishing Group
ISSN:1745-8366
ISSN (Online):1745-8374

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
392521Regulation of aldosterone and cortisol synthesis in hypertension and cardiovascular diseaseEleanor DaviesMedical Research Council (MRC)G0400874Institute of Cardiovascular and Medical Sciences
392522Regulation of aldosterone and cortisol synthesis in hypertension and cardiovascular diseaseEleanor DaviesMedical Research Council (MRC)G0400874Institute of Cardiovascular and Medical Sciences