The Malaria Cell Atlas: single parasite transcriptomes across the complete Plasmodium life cycle

Howick, V. M. et al. (2019) The Malaria Cell Atlas: single parasite transcriptomes across the complete Plasmodium life cycle. Science, 365(6455), eaaw2619. (doi: 10.1126/science.aaw2619) (PMID:31439762) (PMCID:PMC7056351)

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Abstract

Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We profiled the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire life cycle. We then used our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a eukaryotic parasite and an open-access reference dataset for the study of malaria parasites.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Howick, Dr Virginia and Herren, Dr Jeremy
Authors: Howick, V. M., Russell, A. J.C., Andrews, T., Heaton, H., Reid, A. J., Natarajan, K., Butungi, H., Metcalf, T., Verzier, L. H., Rayner, J. C., Berriman, M., Herren, J. K., Billker, O., Hemberg, M., Talman, A. M., and Lawniczak, M. K.N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Science
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
ISSN (Online):1095-9203
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Science 365(6455): eaaw2619
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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