Hachisuka, J. , Omori, Y., Chiang, M. C., Gold, M. S., Koerber, H. R. and Ross, S. E. (2018) Wind-up in lamina I spinoparabrachial neurons. Pain, 159(8), pp. 1484-1493. (doi: 10.1097/j.pain.0000000000001229) (PMID:29578943) (PMCID:PMC6053328)
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Abstract
Wind-up is a frequency-dependent increase in the response of spinal cord neurons, which is believed to underlie temporal summation of nociceptive input. However, whether spinoparabrachial neurons, which likely contribute to the affective component of pain, undergo wind-up was unknown. Here, we addressed this question and investigated the underlying neural circuit. We show that one-fifth of lamina I spinoparabrachial neurons undergo wind-up, and provide evidence that wind-up in these cells is mediated in part by a network of spinal excitatory interneurons that show reverberating activity. These findings provide insight into a polysynaptic circuit of sensory augmentation that may contribute to the wind-up of pain’s unpleasantness.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Hachisuka, Dr Junichi |
Authors: | Hachisuka, J., Omori, Y., Chiang, M. C., Gold, M. S., Koerber, H. R., and Ross, S. E. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | Pain |
Publisher: | Lippincott, Williams & Wilkins |
ISSN: | 0304-3959 |
ISSN (Online): | 1872-6623 |
Published Online: | 23 March 2018 |
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