Benefits of salmon eating on traditional and novel vascular risk factors in young, non-obese healthy subjects

Lara, J.J., Economou, M., Wallace, A.M., Rumley, A., Lowe, G., Slater, C., Caslake, M., Sattar, N. and Lean, M.E.J. (2007) Benefits of salmon eating on traditional and novel vascular risk factors in young, non-obese healthy subjects. Atherosclerosis, 193(1), pp. 213-221. (doi:10.1016/j.atherosclerosis.2006.06.018)

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Abstract

<b>Aim</b>: The present clinical study tested the hypothesis that oil-rich fish consumption improves CHD risk factors. <b>Methods</b>: Forty-eight (16 men) non-obese, healthy adults aged 20–55, consumed 125 g/day of salmon for a 4-week period followed by a 4-week period with no-fish (41 completers). Subjects were instructed to maintain dietary and physical activity patterns during the period of study. Blood pressure, anthropometric, body composition and dietary information with fasting blood samples to determine traditional and novel CHD risk markers and plasma fatty acids were obtained before and after each period. <b>Results</b>: Compared to no-fish, eating salmon significantly decreased systolic, diastolic and mean arterial blood pressure by 4%, triglycerides by 15%, and LDL-cholesterol by 7%, and significantly increased HDL-cholesterol by 5% (P < 0.05). The changes in blood pressure and lipids alone with salmon intake predict around a 25% reduction in CHD risk based on the PROCAM risk calculator. Plasma adiponectin demonstrated a trend towards improvement (8.39 μmol/L with salmon and 7.52 with no-fish; P = 0.086) but no significant changes were found either in plasma leptin, glucose or insulin after salmon consumption. <b>Conclusions</b>: Daily consumption of salmon improves traditional risk predictors of CHD in non-obese subjects. Adiponectin may be involved but the impact on novel risk factors needs study in high-risk subjects.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Caslake, Professor Muriel and Slater, Dr Christine and Lean, Professor Michael and Rumley, Dr Ann and Sattar, Professor Naveed and Lowe, Professor Gordon
Authors: Lara, J.J., Economou, M., Wallace, A.M., Rumley, A., Lowe, G., Slater, C., Caslake, M., Sattar, N., and Lean, M.E.J.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Atherosclerosis
Publisher:Elsevier Ireland Ltd
ISSN:0021-9150
ISSN (Online):1879-1484
Published Online:27 October 2006

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