Predictors of fatigue in rheumatoid arthritis

Druce, K. L. and Basu, N. (2019) Predictors of fatigue in rheumatoid arthritis. Rheumatology, 58(S5), v29-v34. (doi: 10.1093/rheumatology/kez346) (PMID:31435677) (PMCID:PMC6827266)

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Abstract

People with RA commonly experience fatigue. Fatigue is a key contributor to increased clinical care costs, primary care consultations and employment loss. Despite this, our understanding of the prognostic of factors of poor fatigue outcomes is lacking and fatigue is poorly managed. Examining longitudinal predictors of fatigue can identify both individuals ‘at risk’ of poor prognosis, and candidate mechanisms that are worthy of greater inspection. This review discusses the factors most commonly investigated as being implicated in the prognosis of RA fatigue. The available data appears to implicate generic factors such as pain, mental health, disability and sleep as consistent predictors of fatigue outcome, while the role of disease activity and inflammation seems less clear. However, the existing data are not without methodological limitations and there have been no specific studies primarily designed to investigate the inflammatory biomarkers of fatigue. Future studies are required to more comprehensively and robustly determine the mechanisms of fatigue.

Item Type:Articles
Additional Information:Funding: The work in this manuscript was supported by the Centre for Epidemiology Versus Arthritis (formerly Arthritis Research UK) Centre Grant: 21755. This paper forms part of the supplement entitled Fatigue. This supplement was supported by Gilead.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Basu, Professor Neil
Authors: Druce, K. L., and Basu, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Rheumatology
Publisher:Oxford University Press
ISSN:1462-0324
ISSN (Online):1462-0332
Published Online:21 August 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Rheumatology 58:v29-v34
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
21755