Stevens, C. and La Thangue, N.B. (2004) The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair, 3, pp. 1071-1079. (doi: 10.1016/j.dnarep.2004.03.034)
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Abstract
Genotoxic stress triggers a myriad of cellular responses including cell cycle arrest, stimulation of DNA repair and apoptosis. A central role for the E2F-1 transcription factor in the DNA damage response pathway is gaining support. E2F-1 is phosphorylated by DNA damage responsive protein kinases, which leads to E2F-1 accumulation and the induction of apoptosis. In addition, emerging information suggests that E2F-1 may play a role in the detection and subsequent repair of damaged DNA.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | UNSPECIFIED |
| Authors: | Stevens, C., and La Thangue, N.B. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | DNA Repair |
| ISSN: | 1568-7864 |
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