Biointegrated and wirelessly powered implantable brain devices: a review

Das, R. , Moradi, F. and Heidari, H. (2020) Biointegrated and wirelessly powered implantable brain devices: a review. IEEE Transactions on Biomedical Circuits and Systems, 14(2), pp. 343-358. (doi: 10.1109/TBCAS.2020.2966920) (PMID:31944987)

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Abstract

Implantable neural interfacing devices have added significantly to neural engineering by introducing the low-frequency oscillations of small populations of neurons known as local field potential as well as high-frequency action potentials of individual neurons. Regardless of the astounding progression as of late, conventional neural modulating system is still incapable to achieve the desired chronic in vivo implantation. The real constraint emerges from mechanical and physical diffierences between implants and brain tissue that initiates an inflammatory reaction and glial scar formation that reduces the recording and stimulation quality. Furthermore, traditional strategies consisting of rigid and tethered neural devices cause substantial tissue damage and impede the natural behaviour of an animal, thus hindering chronic in vivo measurements. Therefore, enabling fully implantable neural devices, requires biocompatibility, wireless power/data capability, biointegration using thin and flexible electronics, and chronic recording properties. This paper reviews biocompatibility and design approaches for developing biointegrated and wirelessly powered implantable neural devices in animals aimed at long-term neural interfacing and outlines current challenges toward developing the next generation of implantable neural devices.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Heidari, Dr Hadi and Das, Dr Rupam
Authors: Das, R., Moradi, F., and Heidari, H.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:IEEE Transactions on Biomedical Circuits and Systems
Publisher:IEEE
ISSN:1932-4545
ISSN (Online):1932-4545
Published Online:15 January 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in IEEE Transactions on Biomedical Circuits and Systems 14(2):343-358
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
300137Impact Acceleration Account - University of Glasgow 2017Jonathan CooperEngineering and Physical Sciences Research Council (EPSRC)EP/R511705/1Research and Innovation Services
303466HERMESHadi HeidariEuropean Commission (EC)824164ENG - Electronics & Nanoscale Engineering