Formate metabolism in health and disease

Pietzke, M., Meiser, J. and Vazquez, A. (2020) Formate metabolism in health and disease. Molecular Metabolism, 33, pp. 23-37. (doi: 10.1016/j.molmet.2019.05.012) (PMID:31402327) (PMCID:PMC7056922)

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Abstract

Background: Formate is a one-carbon molecule at the crossroad between cellular and whole body metabolism, between host and microbiome metabolism, and between nutrition and toxicology. This centrality confers formate with a key role in human physiology and disease that is currently unappreciated. Scope of review: Here we review the scientific literature on formate metabolism, highlighting cellular pathways, whole body metabolism, and interactions with the diet and the gut microbiome. We will discuss the relevance of formate metabolism in the context of embryonic development, cancer, obesity, immunometabolism, and neurodegeneration. Major conclusions: We will conclude with an outlook of some open questions bringing formate metabolism into the spotlight.

Item Type:Articles
Additional Information:M.P. and A.V. were supported by Cancer Research UK (C596/A21140). J.M. was supported by the FNR-ATTRACT Program (A18/BM/11809970).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vazquez, Alexei
Authors: Pietzke, M., Meiser, J., and Vazquez, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Molecular Metabolism
Publisher:Elsevier
ISSN:2212-8778
ISSN (Online):2212-8778
Published Online:30 July 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Molecular Metabolism 33: 23-37
Publisher Policy:Reproduced under a Creative Commons license

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