3'-phosphoadenosine 5'-phosphate accumulation delays the circadian system

Litthauer, S., Chan, K. X. and Jones, M. (2018) 3'-phosphoadenosine 5'-phosphate accumulation delays the circadian system. Plant Physiology, 176(4), pp. 3120-3135. (doi:10.1104/pp.17.01611) (PMID:29487119)

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Abstract

The circadian system optimizes cellular responses to stress, but the signaling pathways that convey the metabolic consequences of stress into this molecular timekeeping mechanism remain unclear. Redox regulation of the SAL1 phosphatase during abiotic stress initiates a signaling pathway from chloroplast to nucleus by regulating the accumulation of a metabolite, 3′-phosphoadenosine 5′-phosphate (PAP). Consequently, PAP accumulates in response to redox stress and inhibits the activity of exoribonucleases (XRNs) in the nucleus and cytosol. We demonstrated that osmotic stress induces a lengthening of circadian period and that genetically inducing the SAL1-PAP-XRN pathway in plants lacking either SAL1 or XRNs similarly delays the circadian system. Exogenous application of PAP was also sufficient to extend circadian period. Thus, SAL1-PAP-XRN signaling likely regulates circadian rhythms in response to redox stress. Our findings exemplify how two central processes in plants, molecular timekeeping and responses to abiotic stress, can be interlinked to regulate gene expression.

Item Type:Articles
Additional Information:This work was supported by the Leverhulme Trust (ECF-2012-358), The Royal Society (grant no. RG130746), The Oppenheimer Memorial Trust (PhD studentship to S.L.), The Gen Foundation (to S.L.), the University of Essex, and the Australian Research Council Centre of Excellence in Plant Energy Biology (CE140100008).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jones, Dr Matt
Authors: Litthauer, S., Chan, K. X., and Jones, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Plant Physiology
Publisher:American Society of Plant Biologists
ISSN:0032-0889
ISSN (Online):1532-2548
Copyright Holders:Copyright © 2018 American Society of Plant Biologists
First Published:First published in Plant Physiology 176(4):3120 - 3135.
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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