Identifying prognostic structural features in tissue sections of colon cancer patients using point pattern analysis

Jones-Todd, C. M., Caie, P., Illian, J. B. , Stevenson, B. C., Savage, A., Harrison, D. J. and Bown, J. L. (2019) Identifying prognostic structural features in tissue sections of colon cancer patients using point pattern analysis. Statistics in Medicine, 38(8), pp. 1421-1441. (doi:10.1002/sim.8046) (PMID:30488481)

[img]
Preview
Text
193326.pdf - Accepted Version

1MB

Abstract

Diagnosis and prognosis of cancer are informed by the architecture inherent in cancer patient tissue sections. This architecture is typically identified by pathologists, yet advances in computational image analysis facilitate quantitative assessment of this structure. In this article, we develop a spatial point process approach to describe patterns in cell distribution within tissue samples taken from colorectal cancer (CRC) patients. In particular, our approach is centered on the Palm intensity function. This leads to taking an approximate‐likelihood technique in fitting point processes models. We consider two Neyman‐Scott point processes and a void process, fitting these point process models to the CRC patient data. We find that the parameter estimates of these models may be used to quantify the spatial arrangement of cells. Importantly, we observe characteristic differences in the spatial arrangement of cells between patients who died from CRC and those alive at follow up.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Illian, Professor Janine
Authors: Jones-Todd, C. M., Caie, P., Illian, J. B., Stevenson, B. C., Savage, A., Harrison, D. J., and Bown, J. L.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Statistics
Journal Name:Statistics in Medicine
Publisher:Wiley
ISSN:0277-6715
ISSN (Online):1097-0258
Published Online:28 November 2018
Copyright Holders:Copyright © 2018 John Wiley and Sons Ltd
First Published:First published in Statistics in Medicine 38(8):1421-1441
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

University Staff: Request a correction | Enlighten Editors: Update this record

Downloads per month over past year

View more statistics