Long-lived animals with negligible senescence: clues for ageing research

Stenvinkel, P. and Shiels, P. G. (2019) Long-lived animals with negligible senescence: clues for ageing research. Biochemical Society Transactions, 47(4), pp. 1157-1164. (doi: 10.1042/BST20190105) (PMID:31366472)

193157.pdf - Accepted Version



Among several theories to explain the complicated process of human ageing, the mitochondrial oxidative stress hypothesis has received recent attention. Considering that lifespan and ageing rates vary considerably across taxa, a better understanding of factors that lead to negligible or extremely rapid senescence in mammals may generate novel approaches to target human ageing. Several species, such as naked mole rats, ocean quahog, rockfish and Greenland shark, have been identified that exhibit negligible senescence and superior resistance to age-related diseases. Considering that the available literature suggests that their outstanding stress resistance is linked to maintenance of protein homeostasis and robust mitochondrial functions, treatments that target protein modification and upregulation of matrix antioxidants may have implications for extending human health span.

Item Type:Articles
Additional Information:The Heart and Lung Foundation supported Peter Stenvinkel’s research.
Glasgow Author(s) Enlighten ID:Shiels, Professor Paul
Authors: Stenvinkel, P., and Shiels, P. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Biochemical Society Transactions
Publisher:Portland Press
ISSN (Online):1470-8752
Published Online:31 July 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Biochemical Society Transactions 47(4):1157-1164
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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