Neutrophil maturity in cancer

Mackey, J. B.G., Coffelt, S. B. and Carlin, L. M. (2019) Neutrophil maturity in cancer. Frontiers in Immunology, 10, 1912. (doi:10.3389/fimmu.2019.01912)

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Abstract

Neutrophils are implicated in almost every stage of oncogenesis and paradoxically display anti- and pro-tumor properties. Accumulating evidence indicates that neutrophils display diversity in their phenotype resulting from functional plasticity and/or changes to granulopoiesis. In cancer, neutrophils at a range of maturation stages can be identified in the blood and tissues (i.e., outside of their developmental niche). The functional capacity of neutrophils at different states of maturation is poorly understood resulting from challenges in their isolation, identification, and investigation. Thus, the impact of neutrophil maturity on cancer progression and therapy remains enigmatic. In this review, we discuss the identification, prevalence, and function of immature and mature neutrophils in cancer and the potential impact of this on tumor progression and cancer therapy.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mackey, John and Carlin, Dr Leo and Coffelt, Dr Seth
Authors: Mackey, J. B.G., Coffelt, S. B., and Carlin, L. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Frontiers in Immunology
Publisher:Frontiers Media
ISSN:1664-3224
ISSN (Online):1664-3224
Copyright Holders:Copyright © 2019 Mackey, Coffelt and Carlin
First Published:First published in Frontiers in Immunology 10: 1912
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
171961A TRANSGENIC APPROACH TO THE ANALYSIS OF STEM CELL LINEAGE IN THE SKINAllan BalmainCancer Research Campaign (CRC)SP2265/0101RI CANCER SCIENCES
742772CRUK Centre RenewalOwen SansomCancer Research UK (CRUK)C7932/A25142ICS - BEATSON INSTITUTE FOR CANCER RES.
3010100understanding gamma delta T cell function in colorectal cancer metastasisSeth CoffeltWellcome Trust (WELLCOTR)208990/Z/17/ZCS - Beatson Institute for Cancer Research
3018370Insights into the behaviour of anti-metastatic T cellsSeth CoffeltTenovus Scotland (TENOVUS)S17-17CS - Beatson Institute for Cancer Research

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