Impact of foods and dietary supplements containing hydroxycinnamic acids on cardiometabolic biomarkers: a systematic review to explore inter-individual variability

Martini, D. et al. (2019) Impact of foods and dietary supplements containing hydroxycinnamic acids on cardiometabolic biomarkers: a systematic review to explore inter-individual variability. Nutrients, 11(8), 1805. (doi:10.3390/nu11081805) (PMID:31387247)

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Abstract

Plant-based diets rich in bioactive compounds such as polyphenols have been shown to positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the response to these bioactives may affect the findings. This systematic review aimed to summarize findings from existing randomized clinical trials (RCTs) evaluating the effect of hydroxycinnamic acids (HCAs) on markers of CM health in humans. Literature searches were performed in PubMed and the Web of Science. RCTs on acute and chronic supplementation of HCA-rich foods/extracts on CM biomarkers were included. Forty-four RCTs (21 acute and 23 chronic) met inclusion criteria. Comparisons were made between RCTs, including assessments based on population health status. Of the 44 RCTs, only seven performed analyses on a factor exploring inter-individual response to HCA consumption. Results demonstrated that health status is a potentially important effect modifier as RCTs with higher baseline cholesterol, blood pressure and glycaemia demonstrated greater overall effectiveness, which was also found in studies where specific subgroup analyses were performed. Thus, the effect of HCAs on CM risk factors may be greater in individuals at higher CM risk, although future studies in these populations are needed, including those on other potential determinants of inter-individual variability. PROSPERO, registration number CRD42016050790.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Combet Aspray, Dr Emilie
Authors: Martini, D., Chiavaroli, L., González-Sarrías, A., Bresciani, L., Palma-Duran, S. A., Dall’Asta, M., Deligiannidou, G.-E., Massaro, M., Scoditti, E., Combet Aspray, E., Maksimova, V., Urpi-Sarda, M., Kontogiorgis, C. A., Andrés-Lacueva, C., Gibney, E. R., Del Rio, D., Morand, C., Garcia-Aloy, M., Rodriguez-Mateos, A., and Mena, P.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Nutrients
Publisher:MDPI
ISSN:2072-6643
ISSN (Online):2072-6643
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Nutrients 11:1805
Publisher Policy:Reproduced under a Creative Commons License

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