Polymicrobial oral biofilm models: simplifying the complex

Brown, J. L. , Johnston, W., Delaney, C., Short, B., Butcher, M. C., Young, T., Butcher, J., Riggio, M. , Culshaw, S. and Ramage, G. (2019) Polymicrobial oral biofilm models: simplifying the complex. Journal of Medical Microbiology, 68(11), pp. 1573-1584. (doi: 10.1099/jmm.0.001063) (PMID:31524581)

192785.pdf - Accepted Version



Over the past century, numerous studies have used oral biofilm models to investigate growth kinetics, biofilm formation, structure and composition, antimicrobial susceptibility and host–pathogen interactions. In vivo animal models provide useful models of some oral diseases; however, these are expensive and carry vast ethical implications. Oral biofilms grown or maintained in vitro offer a useful platform for certain studies and have the advantages of being inexpensive to establish and easy to reproduce and manipulate. In addition, a wide range of variables can be monitored and adjusted to mimic the dynamic environmental changes at different sites in the oral cavity, such as pH, temperature, salivary and gingival crevicular fluid flow rates, or microbial composition. This review provides a detailed insight for early-career oral science researchers into how the biofilm models used in oral research have progressed and improved over the years, their advantages and disadvantages, and how such systems have contributed to our current understanding of oral disease pathogenesis and aetiology.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Butcher, Mark and Johnston, William and Brown, Dr Jason and Delaney, Mr Christopher and Ramage, Professor Gordon and Riggio, Professor Marcello and Culshaw, Professor Shauna and Young, Ms Tracy
Authors: Brown, J. L., Johnston, W., Delaney, C., Short, B., Butcher, M. C., Young, T., Butcher, J., Riggio, M., Culshaw, S., and Ramage, G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Journal of Medical Microbiology
Publisher:Microbiology Society
ISSN (Online):1473-5644
Published Online:01 November 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Journal of Medical Microbiology 68(11): 1573-1584
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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