Brown, J. L. , Johnston, W., Delaney, C., Short, B., Butcher, M. C., Young, T., Butcher, J., Riggio, M. , Culshaw, S. and Ramage, G. (2019) Polymicrobial oral biofilm models: simplifying the complex. Journal of Medical Microbiology, 68(11), pp. 1573-1584. (doi: 10.1099/jmm.0.001063) (PMID:31524581)
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Abstract
Over the past century, numerous studies have used oral biofilm models to investigate growth kinetics, biofilm formation, structure and composition, antimicrobial susceptibility and host–pathogen interactions. In vivo animal models provide useful models of some oral diseases; however, these are expensive and carry vast ethical implications. Oral biofilms grown or maintained in vitro offer a useful platform for certain studies and have the advantages of being inexpensive to establish and easy to reproduce and manipulate. In addition, a wide range of variables can be monitored and adjusted to mimic the dynamic environmental changes at different sites in the oral cavity, such as pH, temperature, salivary and gingival crevicular fluid flow rates, or microbial composition. This review provides a detailed insight for early-career oral science researchers into how the biofilm models used in oral research have progressed and improved over the years, their advantages and disadvantages, and how such systems have contributed to our current understanding of oral disease pathogenesis and aetiology.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Brown, Dr Jason and Riggio, Professor Marcello and Delaney, Mr Christopher and Culshaw, Professor Shauna and Young, Ms Tracy and Butcher, Mr Mark and Ramage, Professor Gordon and Johnston, William |
Authors: | Brown, J. L., Johnston, W., Delaney, C., Short, B., Butcher, M. C., Young, T., Butcher, J., Riggio, M., Culshaw, S., and Ramage, G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
Journal Name: | Journal of Medical Microbiology |
Publisher: | Microbiology Society |
ISSN: | 0022-2615 |
ISSN (Online): | 1473-5644 |
Published Online: | 01 November 2019 |
Copyright Holders: | Copyright © 2019 The Authors |
First Published: | First published in Journal of Medical Microbiology 68(11): 1573-1584 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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