Suboptimal SVR rates in African patients with atypical Genotype 1 subtypes: implications for global elimination of Hepatitis C

Childs, K. et al. (2019) Suboptimal SVR rates in African patients with atypical Genotype 1 subtypes: implications for global elimination of Hepatitis C. Journal of Hepatology, 71(6), pp. 1099-1105. (doi: 10.1016/j.jhep.2019.07.025) (PMID:31400349)

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Abstract

Direct acting antiviral medications are able to cure Hepatitis C in the majority of patients. The most common genotype of Hepatitis C in Europe and the United States is genotype 1a or 1b and most clinical trials focused on these genotypes. We report that in a group of African patients, most of them had unusual (non-1a/1b) genotype 1 subtypes, and that the cure rate in these unusual genotypes was lower than in genotypes 1a and 1b.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Tong, Dr Lily and Davis, Dr Chris and Da Silva Filipe, Dr Ana and Thomson, Professor Emma
Authors: Childs, K., Davis, C., Cannon, M., Montague, S., Filipe, A., Tong, L., Simmonds, P., Smith, D., Thomson, E. C., Dusheiko, G., and Agarwal, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Hepatology
Publisher:Elsevier
ISSN:0168-8278
ISSN (Online):1600-0641
Published Online:07 August 2019
Copyright Holders:Copyright © 2019 European Association for the Study of the Liver
First Published:First published in Journal of Hepatology 71(6): 1099-1105
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656341Virus-host interactions in hepatitis C virus infectionJohn McLauchlanMedical Research Council (MRC)MC_UU_12014/1MVLS III - CENTRE FOR VIRUS RESEARCH
645101T-cell mediated evolution of hepatitis C virus during acute infectionEmma ThomsonWellcome Trust (WELLCOTR)102789/Z/13/ZMVLS III - CENTRE FOR VIRUS RESEARCH