Combined antifungal resistance and biofilm tolerance: the global threat of Candida auris

Kean, R. and Ramage, G. (2019) Combined antifungal resistance and biofilm tolerance: the global threat of Candida auris. mSphere, 4(4), e00458-19. (doi:10.1128/mSphere.00458-19) (PMID:31366705)

Kean, R. and Ramage, G. (2019) Combined antifungal resistance and biofilm tolerance: the global threat of Candida auris. mSphere, 4(4), e00458-19. (doi:10.1128/mSphere.00458-19) (PMID:31366705)

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Abstract

The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community. Over the past decade, our understanding of how this yeast has spread globally, its clinical importance, and how it tolerates and resists antifungal agents has expanded. This review highlights the clinical importance of antifungal resistance in C. auris and explores our current understanding of the mechanisms associated with azole, polyene, and echinocandin resistance. We also discuss the impact of phenotypic tolerance, with particular emphasis on biofilm-mediated resistance, and present new pipelines of antifungal drugs that promise new hope in the management of C. auris infection.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kean, Mr Ryan and Ramage, Professor Gordon
Authors: Kean, R., and Ramage, G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:mSphere
Publisher:American Society for Microbiology
ISSN:2379-5042
ISSN (Online):2379-5042
Published Online:31 July 2019
Copyright Holders:Copyright © 2019 Kean and Ramage
First Published:First published in mSphere 4(4): e00458-19
Publisher Policy:Reproduced under a Creative Commons License

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