Inflammation and immunity in vascular diseases

McShane, L., Sage, A. P. and Maffia, P. (2019) Inflammation and immunity in vascular diseases. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 229-238. ISBN 9783030164805 (doi:10.1007/978-3-030-16481-2_21)

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Research from the last 20 years has clearly demonstrated a key role for the immune system in the development of various cardiovascular diseases (CVD), with inflammation being shown as an important predictor of disease severity and outcome. However, the gap between research and clinical application remains large, with no therapeutics targeting immunoinflammatory responses routinely used in clinical practice. In this chapter we will briefly describe immune and inflammatory mechanisms in vascular disease, mainly in the context of atherosclerosis. We will discuss how immune cells and mediators drive CVD pathogenesis and affect clinical severity.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Sage, Dr Andrew and McShane, Lucy and Maffia, Professor Pasquale
Authors: McShane, L., Sage, A. P., and Maffia, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Published Online:03 August 2019

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