Radiohalogenation of organic compounds: practical considerations and challenges for molecular imaging

Sutherland, A. (2019) Radiohalogenation of organic compounds: practical considerations and challenges for molecular imaging. Synthesis, 51(23), pp. 4368-4373. (doi: 10.1055/s-0037-1611885)

Abstract

In the last few decades, advances in molecular imaging technologies have had a major impact on many aspects of healthcare. In particular, radiohalogenated compounds have been used for non-invasive visualization of human anatomy, for the diagnosis of disease and in drug development programs. As a consequence of these advances, a range of novel synthetic radiochemical methods have been reported that allow more effective and efficient radiohalogenation from a broader range of precursors. In developing new radiochemical methods, special requirements are required to optimize the incorporation of highly radioactive, short-lived, isotopically labelled reagents. This article highlights the key practical considerations and challenges encountered when utilizing the most commonly used radiohalogens in nuclear medicine.

• Item Type: Articles
• Additional Information: Financial support from the University of Glasgow is gratefully acknowledged.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Sutherland, Professor Andrew
• Authors: Sutherland, A.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Synthesis
• Publisher: Thieme Publishing
• ISSN: 0039-7881
• ISSN (Online): 1437-210X
• Published Online: 03 July 2019
• Copyright Holders: Copyright © 2019 Thieme
• First Published: First published in Synthesis 51(23):4368-4373
• Publisher Policy: Reproduced in accordance with the publisher copyright policy