Barriers and facilitators to reducing anticholinergic burden from the perspectives of patients, their carers, and healthcare professionals: a protocol for qualitative evidence synthesis

Stewart, C., Gallacher, K. , Nakham, A., Cruickshank, M., Newlands, R., Bond, C., Myint, P. K., Bhattacharya, D. and Mair, F. S. (2019) Barriers and facilitators to reducing anticholinergic burden from the perspectives of patients, their carers, and healthcare professionals: a protocol for qualitative evidence synthesis. Journal of Evidence-Based Medicine, 12(3), pp. 227-231. (PMID:31441236)

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Abstract

Anticholinergic drugs are prescribed for a range of conditions including gastrointestinal disorders, overactive bladder, allergies, and depression. While in some circumstances anticholinergic effects are therapeutic, they also pose many undesired or adverse effects. The overall impact from concomitant use of multiple medications with anticholinergic properties is termed anticholinergic burden (ACB). Greater ACB is associated with increased risks of impaired physical and cognitive function, falls, cardiovascular events, and mortality. This has led to the development of interventions aimed at reducing ACB through the deprescribing of anticholinergic drugs. However, little is known about the implementation issues that may influence successful embedding and integration of such interventions into routine clinical practice. In this paper, we present the protocol for our systematic review that aims to identify the qualitative evidence for the barriers and facilitators to reduce ACB from the perspectives of patients, carers, and healthcare professionals. A comprehensive search strategy will be conducted across OVID Medline, EMBASE, PsycInfo, and CINAHL. The review will be conducted in accordance with ENTREQ (Enhancing Transparency in Reporting the Synthesis of Qualitative Research) and has been registered with PROSPERO (Registration CRD42018109084). Normalization process theory (NPT) will be used to explore, understand, and explain qualitative data in relation to factors that act as barriers or facilitators to ACB reduction.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gallacher, Dr Katie and Mair, Professor Frances
Authors: Stewart, C., Gallacher, K., Nakham, A., Cruickshank, M., Newlands, R., Bond, C., Myint, P. K., Bhattacharya, D., and Mair, F. S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
Journal Name:Journal of Evidence-Based Medicine
Publisher:Wiley
ISSN:1756-5383
ISSN (Online):1756-5391
Published Online:22 August 2019
Copyright Holders:
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nese Cochrane Center, West China Hospital of Sichuan University and John Wiley &
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First Published:First published in Journal of Evidence-Based Medicine 12(3):227-231
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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