Contrast agent microbubble-jetting during initial interaction with 200 kHz focused ultrasound

Cleve, S., Inserra, C. and Prentice, P. (2019) Contrast agent microbubble-jetting during initial interaction with 200 kHz focused ultrasound. Ultrasound in Medicine and Biology, 45(11), pp. 3075-3080. (doi: 10.1016/j.ultrasmedbio.2019.08.005) (PMID:31477370)

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Abstract

The initial response of microbubbles flowing through a 500-μm polycarbonate capillary to a burst of 200-kHz focused ultrasound, at peak-negative pressure amplitudes from 0.7–1.5 MPa, was investigated with dual-perspective high-speed imaging. Directed jetting through the acoustic focus is demonstrated according to the pressure gradients acting across the cavitating microbubbles. At lower amplitudes, repeated microbubble-jetting is accompanied by sudden, intermittent translation. At higher amplitudes a rebound jet also forms, before disintegration into a cavitation cloud.

Item Type:Articles
Additional Information:The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement No. 336189 (TheraCav), and EPSRC network+ ThUNDDAR (EP/N026942/1) in the UK. SC acknowledges support from LABEX CeLyA (ANR-10-LABX-0060) of Université de Lyon, Investissements d'Avenir (ANR-11-IDEX-0007) program.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cleve, Sarah and Prentice, Dr Paul
Authors: Cleve, S., Inserra, C., and Prentice, P.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:Ultrasound in Medicine and Biology
Publisher:Elsevier
ISSN:0301-5629
ISSN (Online):1879-291X
Published Online:29 August 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Ultrasound in Medicine and Biology 45(11):3075-3080
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
722331TheraCav - Harnessing Cavitation for TherapyPaul PrenticeEuropean Research Council (ERC)336189ENG - ENGINEERING SYSTEMS POWER & ENERGY
304016Therapy Ultrasound Network for Drug Delivery & Ablation ResearchEP/N026942/1