Reproducibility and repeatability of peripheral microvascular assessment using lontophoresis in conjunction with laser doppler imaging

Jadhav, S., Sattar, N. , Petrie, J. , Cobbe, S. and Ferrell, W. (2007) Reproducibility and repeatability of peripheral microvascular assessment using lontophoresis in conjunction with laser doppler imaging. Journal of Cardiovascular Pharmacology, 50(3), pp. 343-349. (doi:10.1097/FJC.0b013e3180dca094)

Full text not currently available from Enlighten.

Abstract

Interrogation of peripheral vascular function is increasingly recognized as a noninvasive surrogate marker for coronary vascular function and carries with it important prognostic information regarding future cardiovascular risk. Laser Doppler imaging (LDI) is a completely noninvasive method for looking at peripheral microvascular function. We sought to look at reproducibility and repeatability of LDI-derived assessment of peripheral microvascular function between arms and 8 weeks apart. We used LDI in conjunction with iontophoretic application of ACh and SNP to look at endothelium-dependent and -independent microvascular function, respectively, in a mixture of women with cardiac syndrome X and healthy volunteers. We looked at variation between arms (n = 40) and variation at 8 weeks apart (n = 22). When measurements were corrected for skin resistance, there was nonsignificant variation between arms for ACh (2.7%) and SNP (3.8%) and nonsignificant temporal variation for ACh (3.5%) and SNP (4.7%). Construction of Bland-Altman plots reinforce that measurements have good repeatability. Elimination of the baseline perfusion response had deleterious effects on repeatability. LDI can be used to assess peripheral vascular response with good repeatability as long as measurements are corrected for skin resistance, which affects drug delivery. This has important implications for the future use of LDI.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ferrell, Professor William and Petrie, Professor John and Cobbe, Professor Stuart and Sattar, Professor Naveed
Authors: Jadhav, S., Sattar, N., Petrie, J., Cobbe, S., and Ferrell, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Cardiovascular Pharmacology
ISSN:0160-2446

University Staff: Request a correction | Enlighten Editors: Update this record