Simulation of action potential propagation based on the ghost structure method

Wang, Y., Cai, L., Luo, X. , Ying, W. and Gao, H. (2019) Simulation of action potential propagation based on the ghost structure method. Scientific Reports, 9(1), 10927. (doi:10.1038/s41598-019-47321-2)

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Abstract

In this paper, a ghost structure (GS) method is proposed to simulate the monodomain model in irregular computational domains using finite difference without regenerating body-fitted grids. In order to verify the validity of the GS method, it is first used to solve the Fitzhugh-Nagumo monodomain model in rectangular and circular regions at different states (the stationary and moving states). Then, the GS method is used to simulate the propagation of the action potential (AP) in transverse and longitudinal sections of a healthy human heart, and with left bundle branch block (LBBB). Finally, we analyze the AP and calcium concentration under healthy and LBBB conditions. Our numerical results show that the GS method can accurately simulate AP propagation with different computational domains either stationary or moving, and we also find that LBBB will cause the left ventricle to contract later than the right ventricle, which in turn affects synchronized contraction of the two ventricles.

Item Type:Articles
Additional Information:This research was supported by the National Natural Science Foundation of China (Grant Nos 11871399, 11471261) and the Natural Science Foundation of Shaanxi (Grant No. 2017JM1005).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu and Gao, Dr Hao
Authors: Wang, Y., Cai, L., Luo, X., Ying, W., and Gao, H.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN:2045-2322
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Scientific Reports 9(1):10927
Publisher Policy:Reproduced under a Creative Commons License

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